SubtiBank SubtiBank
Version comparison:

2019-06-04 16:21:452025-05-12 12:06:13

locus

BSU00680

BSU_00680

function

purine salvage and interconversion, control of ftsH expression

purine salvage and interconversion, control of [[gene|ftsH]] expression

outlinks

bsu

BSU00680

BSU_00680

The protein

Catalyzed reaction/ biological activity

IMP diphosphate = hypoxanthine 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)

diphosphate + IMP --> 5-phospho-α-D-ribose 1-diphosphate + hypoxanthine (according to UniProt)

diphosphate + GMP --> 5-phospho-α-D-ribose 1-diphosphate + guanine (according to UniProt)

The protein

Effectors of protein activity

inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´[Pubmed|22981860]

inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´, (p)ppGpp binds to the acive site of the enzyme and prevents the conversion of the apo-tetramer to the active dimer [Pubmed|31552824,22981860]

The protein

Structure

[PDB|1J7J] (from ''Salmonella typhimurium'', 51% identity, 73% similarity)

[PDB|6D9Q] (apo-protein) [pubmed|31552824]

[PDB|6D9R] (complex with the substrate PRPP) [pubmed|31552824]

[PDB|6D9S] (complex with ppGpp) [pubmed|31552824]

The protein

[SW|Localization]

cytoplasm (according to Swiss-Prot)

cytoplasm (according to UniProt)

References

Original publications

18179421, 22981860, 24001521, 6408059, 28189581

18179421, 22981860, 24001521, 6408059, 28189581, 31552824

The protein

Kinetic information

KM (PRPP): 166 µM [pubmed|31552824]

KI (pppGpp): 1.7 µM [pubmed|31552824]