2019-06-04 16:21:452025-05-12 12:06:13
locus
BSU00680
BSU_00680
function
purine salvage and interconversion, control of ftsH expression
purine salvage and interconversion, control of [[gene|ftsH]] expression
outlinks
bsu
BSU00680
BSU_00680
The protein
Catalyzed reaction/ biological activity
IMP diphosphate = hypoxanthine 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
diphosphate + IMP --> 5-phospho-α-D-ribose 1-diphosphate + hypoxanthine (according to UniProt)
diphosphate + GMP --> 5-phospho-α-D-ribose 1-diphosphate + guanine (according to UniProt)
The protein
Effectors of protein activity
inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´[Pubmed|22981860]
inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´, (p)ppGpp binds to the acive site of the enzyme and prevents the conversion of the apo-tetramer to the active dimer [Pubmed|31552824,22981860]
The protein
Structure
[PDB|1J7J] (from ''Salmonella typhimurium'', 51% identity, 73% similarity)
[PDB|6D9Q] (apo-protein) [pubmed|31552824]
[PDB|6D9R] (complex with the substrate PRPP) [pubmed|31552824]
[PDB|6D9S] (complex with ppGpp) [pubmed|31552824]
The protein
[SW|Localization]
cytoplasm (according to Swiss-Prot)
cytoplasm (according to UniProt)
References
Original publications
The protein
Kinetic information
KM (PRPP): 166 µM [pubmed|31552824]
KI (pppGpp): 1.7 µM [pubmed|31552824]